La maladie de Dupuytren est une maladie d'origine inconnue qui touche des tissus (les aponévroses) dont le rôle est de protéger les muscles, les nerfs et les vaisseaux. (b) Lactase-associated SNP rs4988235 shows a highly significant decrease in local haplotype sharing. Elles s … It is named after Guillaume Dupuytren, who first described the underlying mechanism of action followed by the first successful operation in 1831 and publication of the results in The Lancet in 1834. The evidence for this assertion comes from two main themes. La maladie de Dupuytren et le syndrome du canal carpien peuvent survenir chez le même patient. Finally, chromosome painting was used to see whether Dupuytren’s disease-associated single nucleotide polymorphisms are geographically structured. English new terms dictionary; Interpretations; Translations; Books; English new terms dictionary  Dupuytren's contracture. The local painting for the 21 independent Dupuytren’s GWAS hits was extracted and the frequency for which individuals with each population label shared a most recent haplotype with individuals of each other population was calculated, to form a population co-ancestry matrix for each position in the genome. Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. Affections associées. Get the News Letter from Dupuytren Research Group, Information for Scientists and Clinicians, Dupuytren Research Group 2012 Research Grants. Maladie de Dupuytren La maladie de Dupuytren est une affection de la main caractérisée par une flexion progressive et irréductible de certains doigts. Elle entraîne une rétraction et une flexion progressive et irréductible des doigts. FST for each SNP was calculated using Hudson’s estimator of FST (Hudson et al., 1992), as implemented in EIGENSOFT (https://www.hsph.harvard.edu/alkes-price/software/). (J Hand Surg 2002;27A:385–390. Sharing links are not available for this article. Elle a été décrite en 1831 par le baron Dupuytren, chirurgien à l'Hôtel-Dieu de Paris. Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and intermarried. La maladie de Dupuytren est pratiquement inexistante en Afrique et en Asie. contact » ou porteur d`Entérocoque. The entire cohort was plotted against theoretical quantiles to demonstrate the normality of the data (upper right panel). Dupuytren disease has been referred to as a Viking or Celtic disease, but existed in Europe earlier than the Viking Age8345270 and originated much earlier in prehistory 12015711. View or download all the content the society has access to. Finally, a GRS derived from DD-associated SNPs did not show increased geographical clustering around areas of known high Norse ancestry. James Barrie, author of “Peter Pan” had a right contracture thought to be Dupuytren’s, which formed the source material for Captain Hook’s hook. See Table 1 for an explanation of the terms used in this study. Ethical approval for this study was obtained from: British Society for Surgery of the Hand Genetics of Dupuytren’s Disease (BSSH-GODD) study – Oxfordshire Research Ethics Committee B/09/H0605/65; People of the British Isles study – NRES Committee, Yorkshire and the Humber – Leeds West, UK 05/Q1205/35. Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and intermarried. L’atteinte d’autres membres de la famille, avec des formes de sévérité variable, semble indiquer une origine génétique. (b) Orkney vs Wales; (c) Orkney vs South East; (d) Orkney vs Wales and South East. In many cases it is believed to be associated with other medical conditions, although the evidence for such associations is not always clear. To ensure that this method has power, we selected a positive control by repeating this analysis for a Lactase-associated SNP – rs4988235 in MCM6. L'héritage viking (3) : Les Vikings n’ont pas laissé que des vestiges archéologiques. les bons gestes. History of Dupuytren's disease Early History of Dupuytren’s Disease and Surgical Treatments. Download Citation | On Nov 1, 2001, Adrian E. Flatt published The Vikings and Baron Dupuytren's Disease | Find, read and cite all the research you need on ResearchGate ,{i:'fig1-1753193419882851',type:'fig',g:[{m:'10.1177_1753193419882851-fig1.gif',l:'10.1177_1753193419882851-fig1.jpeg',size:'207 KB'}]} What other conditions predispose to Dupuytren? Part 1: the origin of the disease: the curse of the MacCrimmons: the hand of benediction: Cline's contracture, The Vikings and Baron Dupuytren's disease, Isolated populations as treasure troves in genetic epidemiology: the case of the Basques, Quelques aspects epidemiologiques de la maladie de Dupuytren, Clinical associations of Dupuytren's disease, Epidemiological evaluation of Dupuytren's disease incidence and prevalence rates in relation to etiology, Estimation of levels of gene flow from DNA sequence data, Inference of population structure using dense haplotype data, The fine-scale genetic structure of the British population, A genome-wide association study of Dupuytren disease reveals 17 additional variants implicated in fibrosis, A weighted genetic risk score predicts surgical recurrence independent of high-risk clinical features in Dupuytren's disease, Genetic architecture: the shape of the genetic contribution to human traits and disease. L’analyse statistique a été faite sur logiciel Epi info et SPSS. La maladie de Dupuytren est une sclé-rose rétr actile de l aponévrose palmaire moyenne, pouv ant entr aîner la flexion progressive et irréductible d un ou plu- ... leur origine au nive au du tendon long palmaire ou, si ce tendon est absent, au niveau des fibres de l aponévrose antébrac hiale. La maladie de Dupuytren. Dupuytren's disease is currently called a Viking disease on the assumption that the disease was spread to Europe and the British Isles during the Viking Age of the 9th to the 13th centuries. However, there are nine or ten different genes associated with Dupuytren’s and this suggests that it may have evolved on several different occasions. The first author to suggest an origin and spread of Dupuytren's disease was Early who wrote in 1962, "If one postulates the condition as having arisen in one particular racial group (the Nordic for example) then the variable distribution in other parts of the world might be explained on the basis of migration from that group." For each comparator group, the total FST of the DD-associated SNPs was not within the top 5% of ranked total FST of 10,000 permuted SNP groups (nominally p > 0.05, Figure 1(b,c,d). J'ai du mal à étirer mes doigts. The authors wish to acknowledge all of the individuals who participated in both studies. The recruitment, genotyping, imputation and analysis methods for the BSSH-GODD and PoBI studies have been previously described (Leslie et al., 2015; Ng et al., 2017). La Dystonie . Compared with 500 random samples of 21 SNPs taken from across the genome, the DD-associated SNPs do not show an increase in within-population structure (p = 0.072, Figure 2(a)), which would have been expected had DD been associated with Norse ancestry. L'origine de cette maladie est inconnue. enacademic.com EN. The first author to suggest an origin and spread of Dupuytren's disease was Early who wrote in 1962, "If one postulates the condition as having arisen in one particular racial group (the Nordic for example) then the variable distribution in other parts of the world might be explained on the basis of migration from that group." This site uses cookies. Some scepticism as to the Norse origin of the disease has been expressed by Elliot (1988). (Classification). Although its management is undertaken by hand surgeons, it is commonly seen by other doctors as an incidental finding. Dupuytren disease has been referred to as a Viking or Celtic disease, but existed in Europe earlier than the Viking Age8345270 and originated much earlier in prehistory 12015711 . We then permuted 10,000 random sets of 21 SNPs within the PoBI dataset and calculated the total FST of each of these sets in each of the three comparator groups. It is believed that this hand deformity originated with the Vikings and they spread it in Northern Europe and far beyond as they married the locals when travelling around the world. Simply select your manager software from the list below and click on download. Data used in this study are available from the European Genome-Phenome Archive (https://ega-archive.org), study numbers EGAS00001000672 and EGAS00001001206, The distribution of genomic FST in both cases and controls closely followed a normal distribution (Figure 1(a)). We hypothesized that if DD were of Norse origin, cases would have a higher average total FST than controls. In all analyses, no evidence was found for an excess of Norse ancestry in Dupuytren’s disease. Le traitement classique était chirurgical, … Six gènes en rapport avec la maladie ont été mis en évidence. Mesures d`hygiène : tenue de base, précautions. The email address and/or password entered does not match our records, please check and try again. Other phenotypes, such as educational attainment, show strong associations with geography on this scale (Timpson et al., 2018). We identified the common SNPs between the PoBI dataset and BSSH-GODD dataset and removed multi-allelic SNPs and non-autosomal SNPs, leaving a set of 462,930 SNPs for further analysis. Le travail prolongé avec les mains n’est pas responsable de la maladie de Dupuytren. Madrid; Santander; Spécialités . En 1831, Guillaume Dupuytren était considéré comme le plus grand chirurgien d’Europe ().Sa présentation orale d’un cas de « rétraction des doigts par suite d’une affection de l’aponévrose palmaire » eut un retentissement immédiat en France et en Angleterre et fut à l’origine d’une polémique sur son étiologie et son traitement qui n’est pas encore terminée. La maladie de Dupuytren est une maladie génétique. Dupuytren’s disease (DD) is an ancient affliction of unknown origin. ,{i:'fig1-1753193419882851',type:'fig',g:[{m:'10.1177_1753193419882851-fig1.gif',l:'10.1177_1753193419882851-fig1.jpeg',size:'207 KB'}]} Dupuytren’s disease, Morbus Dupuytren or palmar fibromatosis, sometimes also called DD, Dupuytren’s contracture, or Viking disease, is a chronic disease that produces a benign thickening of the connective tissue, or fascia, of the palm and fingers. In addition, with the exception of a high prevalence rate in Northern European communities, no actual genetic factors have implicated DD as … Because we were interested in those SNPs that differentiated Orkney from the other populations, all negative FST values were set to zero (Garagnani et al., 2009). ,{i:'table2-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table2.gif',l:'10.1177_1753193419882851-table2.jpeg',size:'102 KB'}]} Selon ce spécialiste de l’appareillage de la main et du membre supérieur, “le doigt à la. La maladie de Dupuytren ou contracture de Dupuytren est une fibrose rétractile de l'aponévrose palmaire (une membrane située entre les tendons fléchisseurs et la peau). It is defined by Dorland as shortening, thickening, and fibrosis of the palmar fascia producing a flexion deformity of a finger. If DD had been disseminated around Europe by the Norsemen, mention of it in one of these sources would be expected. La maladie de Dupuytren est une maladie d’origine inconnue qui touche des tissus (les aponévroses) dont le rôle est de protéger les muscles, les nerfs et les vaisseaux. In addition, we thank the surgeons and researchers in the BSSH-GODD study who helped with recruitment of affected individuals. Furthermore, Elliot (1988) also comments on the lack of records of DD in the medical writings of the missionaries of Iona, the Roman Church in North Germany and North-East England, or the extensive medical writings from mediaeval Europe. The medical terminology used for this kind of a hand deformity is Dupuytren's contracture. Cette pathologie touche notamment les hommes âgés de plus de 40 ans et également les diabétiques. This work was supported by the NIHR Biomedical Research Centre, Oxford. There has been a much quoted concept of DD being labeled as the “Viking“ or “Nordic“ disease. Wright’s Fixation Index (FST) analysis reveals no evidence of a Norse origin of Dupuytren’s Disease (DD). Table 1. Also, Hindocha et al., (2009) stated: ‘Other than the common prevalence of DD in Scandinavia, no objective scientific evidence has been found to date to support and substantiate the “Nordic” origin of the disease’. RAPPEL La maladie décrite en 1831 par le Baron Guillaume Dupuytren, chirurgien de l’Hôtel-Dieu de Paris, est génétique et d’origine Viking. He commented on the fact that ‘It is surprising that no earlier reference to this condition has been found in the Scandinavian literature’. Copyright © 2002 by the … Copyright © 2002 by the … This was the first time Dupuytren had been described as a “Viking disease”, something which has since been repeated over and over – and over. View or download all content the institution has subscribed to. However, there are nine or ten different genes associated with Dupuytren’s and this suggests that it may have evolved on several different occasions. On pense que la maladie de Dupuytren a une origine nordique et ce sont les invasions des Vikings au 12 e siècle qui aurait propagé le gène en Europe et dans les colonies françaises et anglaises. It has been suggested that Dupuytren’s disease has an origin in Norse countries. Une prédisposition héréditaire est souvent retrouvée. La maladie de Dupuytren atteint 216 d’entre eux, soit une prévalence de 7,1%. Dupuytren’s disease (DD) is an ancient affliction of unknown origin. Les fibres longitudinales prennent leur origine au nive au du tendon long palmaire ou, si ce tendon est absent, au niveau des fibres de l aponévrose antébrac hiale. Happy Holidays from the Dupuytren Research Group! En effet les patients atteints de la maladie de Dupuytren notamment serait plus enclin à développer une maladie de Lapeyronie (l’association Dupuytren – maladie de lapeyronie a été retrouvée dans 10 à 15% des cas). Les invasions des Vikings restent le facteur … Pour des raisons mal connues, ces tissus deviennent épais, se pelotonnent d’abord en boule (les nodules) ce qui entraîne des plis dans la paume ou les doigts. Garagnani, P, Laayouni, H, Gonzalez-Neira, A. Gebereegziabher, A, Baraki, A, Kebede, Y, Mohammed, I, Finsen, V. Lawson, DJ, Hellenthal, G, Myers, S, Falush, D. Timpson, NJ, Greenwood, CMT, Soranzo, N, Lawson, DJ, Richards, JB. window.figureViewer={doi:'10.1177/1753193419882851',path:'/na101/home/literatum/publisher/sage/journals/content/jhsc/2020/jhsc_45_3/1753193419882851/20200212',figures:[{i:'table1-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table1.gif',l:'10.1177_1753193419882851-table1.jpeg',size:'616 KB'}]} For more information view the SAGE Journals Article Sharing page. People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population, The British Society for Surgery of the Hand. Figure 2. L'affection est souvent bilatérale. La maladie de Dupuytren ou contracture de Dupuytren est une fibrose rétractile de l'aponévrose palmaire (une membrane située entre les tendons fléchisseurs et la peau). hygiène des mains. We found no evidence for an excess of Norse ancestry informative markers in our cases and the total FST of disease-associated SNPs was not in the top 5% of 10,000 randomly permuted SNP groups of the same size. In conclusion, our genetic analyses directly contradict the widely held belief, especially popular among patients, that DD is a disease of Norse origin. Whaley and Elliot (1993) provided an account of four ‘miracles’ from Nordic sources, where a condition resembling DD was alleviated by miracle cures. Other than the common prevalence of DD in Scandinavia, no objective scientific evidence has been found to support and substantiate the “Nordic“ origin of this disease. Lactase is under positive selection and therefore is expected to show much less population-specific haplotype sharing, and is therefore a positive control in this analysis. A nominal threshold of significance of 0.05 was set, with the hypothesis that if DD is associated with Norse ancestry, the total FST of the DD-associated SNP set would be in the top 5% of permuted sets. Why Is Dupuytren's Contracture Called Viking Disease? For each analysis, FST was calculated between three comparator groups: Orkney vs Wales, Orkney vs South East, and Orkney vs combined Wales and South East. Origines et signes de la maladie. First, epidemiological studies have shown that DD is more common in European populations and the prevalence seems to be highest in Iceland and Scandinavian countries that were the origin of the Viking Warriors (Hindocha et al., 2009). It is the most common inherited disease of the connective tissue and its prevalence is increasing (Bebbington and Furniss, 2015). To make a fair null hypothesis, we sampled the same number of random genome-wide SNPs that make up the risk score using 500 random samples of 21 SNPs. If you have access to a journal via a society or association membership, please browse to your society journal, select an article to view, and follow the instructions in this box. Maladie de Dupuytren sur l’auriculaire La maladie hépatique alcoolique est une maladie hépatique due à l’abus d’alcool pendant une période prolongée. Cette maladie est en partie d’origine génétique et apparaît le plus souvent vers la cinquantaine chez l’homme et plus tardivement chez la femme. In: Mcfarlane RM MD, Flint MH (Eds). If DD were of Norse origin, we would expect that cases would have a higher average total FST than controls. Written informed consent was obtained from all subjects before the study. Total FST of the remaining 21 DD-associated SNPs was calculated, using each of the three comparator groups. Maladie de Dupuytren, une orthèse pour maintenir le doigt en extension Une orthèse pour maintenir un doigt en extension après une opération de Dupuytren ©J.Redoux. The 95% confidence intervals for each region overlap, consistent with the notion that DD and Norse ancestry do not cluster together. Dupuytren’s disease (DD) is a disease of the palmar fascia that causes flexion contractures of the fingers (Townley et al., 2006). Dupuytren's contracture is a non-specific affliction, but primarily affects: Non-modifiable Edit People of Scandinavian or Northern European ancestry; [13] it has been called the "Viking disease", [6] though it is also widespread in some Mediterranean countries, e.g., Spain [14] and Bosnia. Access to society journal content varies across our titles. forum pour la maladie de Dupuytren et maladie de Ledderhose; Dupuytren Society ... Dupuytren Society se réserve le droit de supprimer tout message contenant de la publicité, ainsi que toute information dont le contenu serait illicite ou inadéquat. Elles The PoBI dataset was searched for the statistically most highly associated SNP from each credible set. Viking legacy makes a great story. l’importance de la maladie de Dupuytren. Au fur et à mesure que la maladie évolue, ces tissus se rétractent entraînant la … For all comparator groups, the 95% confidence intervals of the difference between means crossed zero meaning there was no significant difference. Dupuytren's disease typically starts at the age of 50 to 60, though even children have been reported to suffer from Dupuytren's disease (example of a 10 year old boy: "Dupuytren's disease in a child: a case report" Dupuytren_child_abstract). We then aggregated these scores across the 35 population labels to investigate possible geographical structure associated with known regions of high Norse ancestry, such as the Highlands of Scotland. http://www.creativecommons.org/licenses/by/4.0/, https://us.sagepub.com/en-us/nam/open-access-at-sage, https://www.hsph.harvard.edu/alkes-price/software/, Common variants of the ALDH2 and DHDH genes and the risk of Dupuytren’s disease, Radiotherapy in Dupuytren’s disease: a systematic review of the evidence, Egawa T, Senuri S, Horiki A, Egawa M. Epidemiology of the Oriental patient. First, we compared the summed total FST for Norse ancestry informative markers from PoBI in cases and controls in BSSH-GODD. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. We hypothesized that if DD were of Norse origin, the total FST our associated SNPs would be in the top 5% of the ranked total FST for the random permutations of SNPs (nominally p < 0.05). Tombe viking de Locmaria (ile de Groix), ... La première, maladie de Dupuytren (du nom du chirurgien, Le baron Guillaume Dupuytren(1777-1835) qui l’a décrite en 1831) ... entrainant des réactions du corps à l’origine de ces maladies. This product could help you, Accessing resources off campus can be a challenge. Exceptionnelle chez les Asiatiques (1 seul cas), les Africains (à peine 8 cas répertoriés) et les Indiens (10 cas décrits) , la maladie de Dupuytren survient seulement chez les sujets blancs, européens du nord (Islande, Scandinavie, Russie, Angleterre) et chez leurs descendants, en particulier dans les pays d'émigration britannique (Canada, États-Unis, Australie). Compared with previous reports (Whaley and Elliot, 1993), our data provide objective evidence of the lack of Norse origin of the disease. The higher the index for a particular single nucleotide polymorphism (SNP), the more different the allele frequencies of the SNP are between populations. ,{i:'fig2-1753193419882851',type:'fig',g:[{m:'10.1177_1753193419882851-fig2.gif',l:'10.1177_1753193419882851-fig2.jpeg',size:'1 MB'}]} The hypothesis was tested by comparing the within-population co-ancestry to the mean outside-population co-ancestry, by computing the relative frequency of sharing ancestry within a population to that of sharing ancestry with an individual from a different population. Elle est plus fréquente chez les hommes, les diabétiques ou en cas de consommation chronique d’alcool. Login failed. You can be signed in via any or all of the methods shown below at the same time. It is defined by Dorland as shortening, thickening, and fibrosis of the palmar fascia producing a flexion deformity of a finger. Fiche Canal Carpien - Institut de la main. It sounds believable. It usually begins with a small lump, called a nodule, in the palm or fingers that is often mistaken for a blister or callus. Lore has it that they spread it throughout northern Europe. La maladie de Dupuytren est caractérisée par une rétraction des doigts secondaire à une prolifération de tissu fibreux rétractile dans l’aponévrose palmaire et ses prolongements dans les doigts.

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